Figure 5.
C/EBPα induction drives similar pathways in both cell lines. (A-B) C/EBPα induction predominantly upregulates target genes in both Kasumi-1 and SKH1 cells. Table showing numbers of either (A) upregulated or (B) downregulated genes, which are bound by either RUNX1-ETO or RUNX1-EVI1, with and without C/EBPα. Bar graph showing this data as a percentage of differentially expressed genes. (C-D) Enriched KEGG pathways identified from genes differentially expressed after C/EBPα induction and bound by either C/EBPα, RUNX1-ETO, or RUNX1-EVI1. KEGG pathway from (C) upregulated genes and (D) downregulated genes.