Profiling of TMD8^R Cells Reveal Increased PI3Kγ and PTEN loss. (A) Decreased expression of PTEN (9 fold) in TMD8^R clones as compared to TMD8^S (B) Overexpression of PI3Kγ (3-5 fold) in TMD8^R clones as compared to TMD8^S (C) PI3Kδ isoform is the highest expressed isoform in both TMD8^S and TMD8^R clones.