The effect of the extent of glycolytic metabolism on drug sensitivity of leukemic blasts. A. The extent of glycolytic metabolism in different cell types as determined by the % FCCP-inhibition of PMET. Values for individual BM samples, and averages of at least 3 separate experiments for resting T cells: 10, activated T cells: 63, normal BM: 62, HL60r⁰: 100, HeLaS3 r⁰: 99, HeLa r⁰: 98, BW1199: 74, EL4: 48, A20: 45, Molt-4: 30, HeLaS3: 37, U226: 6, HL60L 2, HeLa: 1, RPMI8226: 0. * p=0.0001 between highly glycolytic (n= 9) and moderately glycolytic (n= 13) AML blasts. B. Sensitivity of AML blasts to ATRA, ATO and combined ATRA+ATO, measured as [% viable blast after treatment]/[% viable blasts in controls]. Results are presented as average ± SEM of 4 highly glycolytic AML blasts (black bars) and 5 moderately glycolytic AML blasts (grey bars). * p=0.025