Figure 1.
CONSORT diagram of the ASPEN and LTE1 studies. ∗Reasons for treatment discontinuation (n = 5 left the study, n = 2 remained in the study): other (n = 3); AEs (n = 2); PD (n = 1); and withdrawal (n = 1). †Reasons for study discontinuation (n = 5): death (n = 3); lost to follow-up (n = 1); and withdrawal (n = 1). DBL, database lock; mut, mutated; R/R, relapsed/refractory; TN, treatment naive.