Generation of CABIN1-mutant mouse model and phenotypic characterization. (A) CABIN1 compound heterozygous mutations in the iMCD-IC patient identified by whole-exome sequencing. (B) Generation of mutant mice harboring germ line CABIN1 gene mutations using CRISPR/Cas9 technique. (C) Kaplan-Meier survival curve and clinical score after LCMV CL13 infection. WT and CABIN1-mutated mice were infected with LCMV CL13. Mortality (left) and morbidity (right) were assessed over time. Data from N = 4 to 8 mice from 2 independent experiments are shown.