Changes in PedsQL total and domain scores in adolescents in the PES after exa-cel infusion. (A) Mean changes in PedsQL total score, psychosocial score, and physical score from BL at months 12 and 24. (B) Mean changes in the psychosocial domains from BL at months 12 and 24. Dotted lines indicate the MCID for each measure. Error bars indicate standard error of the mean. BL is defined as the most recent nonmissing measurement (scheduled or unscheduled) collected before the start of mobilization. ∗Total score summarizes questions from the psychosocial and physical scores. ∗∗Psychosocial score summarizes questions from the emotional, social, and school function domains in panel B.