Figure 4.
PAI-1 expression is strongly correlated with the expression of direct FXR target genes in the liver. (A-F) Expression levels of FXR and FXR direct target genes and their association with PAI-1 in the livers of mice fed an ND or an HFD for 4 months (N = 12). Relative Serpine1 mRNA (G) and PAI-1 protein levels (H) in the supernatant of cultured medium, and (I-J) PAI-1 protein levels in MPHs treated with different concentrations of palmitic acid for 12 hours (N = 4). (K-P) mRNA expression levels of FXR and FXR direct target gene mRNAs and their associations with Serpine1 mRNA after treatment of MPHs and different concentrations of palmitic acid for 12 hours (N = 4). The data are represented as the mean ± SEM, n.s. P > .05; ∗∗P < .01; ∗∗∗P < .001 vs the BSA group. BSA, bovine serum albumin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; n.s., no significance.

PAI-1 expression is strongly correlated with the expression of direct FXR target genes in the liver. (A-F) Expression levels of FXR and FXR direct target genes and their association with PAI-1 in the livers of mice fed an ND or an HFD for 4 months (N = 12). Relative Serpine1 mRNA (G) and PAI-1 protein levels (H) in the supernatant of cultured medium, and (I-J) PAI-1 protein levels in MPHs treated with different concentrations of palmitic acid for 12 hours (N = 4). (K-P) mRNA expression levels of FXR and FXR direct target gene mRNAs and their associations with Serpine1 mRNA after treatment of MPHs and different concentrations of palmitic acid for 12 hours (N = 4). The data are represented as the mean ± SEM, n.s. P > .05; ∗∗P < .01; ∗∗∗P < .001 vs the BSA group. BSA, bovine serum albumin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; n.s., no significance.

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