Figure 5.
Innate and EBV-adaptive immune compromise in CAEBV. (A-B) (Top) UMAP embedding of PBMCs colored by IFN-α response score (A) and IFN-β response score range (B). The score was calculated using gene sets termed “GOBP_ GOBP_RESPONSE_TO_INTERFERON_ALPHA (GO:0035455)” and “GOBP_RESPONSE_TO_INTERFERON_BETA (GO:0035456).” (Bottom) Heat maps depicting the average scores in each of 22 cell types. The module score of “EBV-infected NK” was compared with the “NK” score using a 2-sided Welch t test. (C) UMAP embedding of T cells colored by clonal expansion size. Clonal expansion divided into 3 categories (left) and clonal expansion sizes ranging from 0 to 250 (right) are shown. (D) Distribution of the clone status of T cells suspected to be specific to EBV based on the CDR3 amino acid sequence in CAEBV (n = 6), IM (n = 2), or healthy volunteers (n = 2). (E) Rate of EBV-specific T cells with the TCR specific for LMP2 in CAEBV (n = 6), IM (n = 2), or healthy volunteers (n = 2). The difference in the rate of TCR specific to LMP2 between CAEBV and IM was evaluated using the Fisher exact test. cDC, conventional dendritic cell; dnT, double negative T; gdT, γδ T; HSPC, hematopoietic stem and progenitor cell; MAIT, mucosal associated invariant T; pDC, plasmacytoid dendritic cell; Treg, regulatory T.

Innate and EBV-adaptive immune compromise in CAEBV. (A-B) (Top) UMAP embedding of PBMCs colored by IFN-α response score (A) and IFN-β response score range (B). The score was calculated using gene sets termed “GOBP_ GOBP_RESPONSE_TO_INTERFERON_ALPHA (GO:0035455)” and “GOBP_RESPONSE_TO_INTERFERON_BETA (GO:0035456).” (Bottom) Heat maps depicting the average scores in each of 22 cell types. The module score of “EBV-infected NK” was compared with the “NK” score using a 2-sided Welch t test. (C) UMAP embedding of T cells colored by clonal expansion size. Clonal expansion divided into 3 categories (left) and clonal expansion sizes ranging from 0 to 250 (right) are shown. (D) Distribution of the clone status of T cells suspected to be specific to EBV based on the CDR3 amino acid sequence in CAEBV (n = 6), IM (n = 2), or healthy volunteers (n = 2). (E) Rate of EBV-specific T cells with the TCR specific for LMP2 in CAEBV (n = 6), IM (n = 2), or healthy volunteers (n = 2). The difference in the rate of TCR specific to LMP2 between CAEBV and IM was evaluated using the Fisher exact test. cDC, conventional dendritic cell; dnT, double negative T; gdT, γδ T; HSPC, hematopoietic stem and progenitor cell; MAIT, mucosal associated invariant T; pDC, plasmacytoid dendritic cell; Treg, regulatory T.

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