Mutational landscape of CAEBV according to CIMP status. (A) Gene mutations and CNAs in NK cell–type CAEBV with different CIMP status. (B) Pairwise associations among mutated genes found in at least 3 patients with NK cell–type or T-cell–type CAEBV and PD-related death outcome. Only significant correlations (q < .05) are shown together with their odds ratios. ARID1A and KMT2D mutations and CD274 3′-UTR SVs are defined as risk genes and highlighted in red. (C) Kaplan-Meier survival curves for NK cell–type or T-cell–type CAEBV according to risk gene mutations. The table below the plot indicates the number of patients at risk at each time point. (D) Forest plots of multivariate analyses of OS in NK cell–type or T-cell–type CAEBV constructed using the Cox proportional hazard model (hazard ratio ± 95% CI). Risk genes and known clinical prognostic factors were included in the model. AIC, Akaike information criterion; WES, whole-exome sequencing; WGS, whole-genome sequencing.