ATAC-seq of AML-exposed neutrophils reveals increased DAPs for IRF8 and C/EBPβ affecting neutrophil function. (A) Principal component analysis of ATAC-seq data from sorted healthy (n = 3) and AML-exposed neutrophils (n = 4) for each neutrophil subpopulation. (B) Heat map was generated displaying DAPs in regions closed in AML (decreased) and regions open in AML (increased) for neutrophils from subpopulation NEU2 (Ly6GHiCD101–). (C) De novo motif discovery of DAPs open in AML. (D) De novo motif discovery of DAPs closed in AML. (E) Volcano plot displaying genes nearest to DAPs in AML-exposed (red) vs healthy Ly6GHiCD101 neutrophils (blue). All DAPs have fold change >1.5; P ≤ .05.
Figure 4.

ATAC-seq of AML-exposed neutrophils reveals increased DAPs for IRF8 and C/EBPβ affecting neutrophil function. (A) Principal component analysis of ATAC-seq data from sorted healthy (n = 3) and AML-exposed neutrophils (n = 4) for each neutrophil subpopulation. (B) Heat map was generated displaying DAPs in regions closed in AML (decreased) and regions open in AML (increased) for neutrophils from subpopulation NEU2 (Ly6GHiCD101–). (C) De novo motif discovery of DAPs open in AML. (D) De novo motif discovery of DAPs closed in AML. (E) Volcano plot displaying genes nearest to DAPs in AML-exposed (red) vs healthy Ly6GHiCD101 neutrophils (blue). All DAPs have fold change >1.5; P ≤ .05.

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