Stromal and ALK⁺ ALCL cell bidirectional crosstalk in the presence of crizotinib. (A) Venn diagram of the DEGs in MS-5 cells cultured alone vs MS-5 cocultured with SUPM2 or L82 cells for 72 hours. (B) Dot plot reporting the up- and downregulation of HALLMARKS in MS-5 cells cultured alone vs MS-5 cocultured with SUPM2 or L82 cells for 72 hours. The color of the dots indicates the P value adjusted, whereas their size relates to the fold enrichment. (C) Circos plot of the L-R interactions between MS-5 and L82 cells treated with 50 to 100 nM of crizotinib for 72 hours. Ligands are depicted in green, whereas receptors are in red. Interactions are colored differently based on their function. (D) Circos plot of the L-R interactions between MS-5 and SUPM2 cells treated with 50 to 100 nM of crizotinib for 72 hours. Ligands are depicted in green, whereas receptors are in red. Interactions are colored differently based on their function. GPCR, G protein-coupled receptor; RTK, receptor tyrosine kinase.