G6b expression and YKL-40 secretion correlate with platelet counts in patients with MF. Thrombocytopenia is a common symptom of MF and can be exacerbated upon treatment with JAK2 inhibitors. In nonthrombocytopenic patients with MF, MKs express high levels of the MK and platelet inhibitory receptor G6b, which correlates to high GATA-1 levels and sufficient cytoplasmic maturation. Thrombocytopenia in MF, however, is associated with impaired G6b expression, low GATA-1 levels and increased inflammatory cytokine secretion. Autocrine and paracrine signaling of both the secreted glycoprotein YKL-40 and the profibrotic TGFβ1 further attenuate MK maturation. The figure was created with BioRender.com. Roweth H. (2025) https://BioRender.com/up5g4as.

G6b expression and YKL-40 secretion correlate with platelet counts in patients with MF. Thrombocytopenia is a common symptom of MF and can be exacerbated upon treatment with JAK2 inhibitors. In nonthrombocytopenic patients with MF, MKs express high levels of the MK and platelet inhibitory receptor G6b, which correlates to high GATA-1 levels and sufficient cytoplasmic maturation. Thrombocytopenia in MF, however, is associated with impaired G6b expression, low GATA-1 levels and increased inflammatory cytokine secretion. Autocrine and paracrine signaling of both the secreted glycoprotein YKL-40 and the profibrotic TGFβ1 further attenuate MK maturation. The figure was created with BioRender.com. Roweth H. (2025) https://BioRender.com/up5g4as.

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