Figure 3.
![OR4N5 is significantly reduced in CTCL. (A) Expression of OR4N5 (magenta), p38γ (red), and CD3 (green) was measured by immunofluorescence confocal microscopy in CTCL PBMC samples compared with normal healthy donors. Most CTCL cells showed weaker CD3 positivity (green) than control healthy PBMCs. (B) p38γ levels were measured by WB analysis (top). OR4N5 was significantly reduced in CTCL PBMC samples (patient [P1] with SS is shown), with statistical analysis of magenta expression presented (bottom) using Zen Software. GAPDH, glyceraldehyde-3-phosphate dehydrogenase, HD, healthy donor; P, patient.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodneoplasia/2/4/10.1016_j.bneo.2025.100101/1/bneo_neo-2024-000458-gr3.jpeg?Expires=1761273858&Signature=KO7L91MxEE-R0tADamSBqUC8qby8NUcmWzn~T3~zASPL~1IvGx0LgNfbbk5OpysSdTEitb0rxYAm5K4IPM1vhCPp8I0te2kXzo8UAvntCHxUtfNkgB0KP1bJ8~K28Wu4AoEjIifXCKt401~kY6Uf9ROEHMw32NtQp8tElr3fF3VsYW~jEE1ryA~bBseUvh071x5QCd~wVva6kvrUS0Q9DjL0iyDAAAz9dIUsf65GxDDbaHnqtZGpd5NHZ5~dbUWflNftX7gkJFpcJrdoX1rAWZxbWirh4C0ElQcKTwAPI9qUXL8IZYxgu9PMQ9U5FhUv~qa209gy2ocLuyP~OS31Dw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
OR4N5 is significantly reduced in CTCL. (A) Expression of OR4N5 (magenta), p38γ (red), and CD3 (green) was measured by immunofluorescence confocal microscopy in CTCL PBMC samples compared with normal healthy donors. Most CTCL cells showed weaker CD3 positivity (green) than control healthy PBMCs. (B) p38γ levels were measured by WB analysis (top). OR4N5 was significantly reduced in CTCL PBMC samples (patient [P1] with SS is shown), with statistical analysis of magenta expression presented (bottom) using Zen Software. GAPDH, glyceraldehyde-3-phosphate dehydrogenase, HD, healthy donor; P, patient.
