Patients with OHI+ lymphoma have decreased 3-year OS and EFS. Kaplan-Meier curves comparing the 3-year OS (A) and EFS (B) between OHI− (70 patients) and OHI+ patients (65 patients). Statistical significance was determined using the log-rank (Mantel-Cox) test (∗∗∗∗P < .0001). An event was defined as death, refractoriness, progression, or relapse of lymphoma. (C) Predicted survival of OHI− and OHI+ patients based on the lymphoma-relevant prognostic indexes (left) and the observed survival (right). Statistics were calculated using the χ2 test. ∗∗∗∗P < .0001. (D) Forest plot of the OR and 95% CI of the predicted OHI+/− and the observed survival of patients with OHI+/− lymphoma. The number of patients at risk at each time point is shown beneath the survival curves. ns, nonsignificant.