Figure 3.
Recovery of PLTs after CAR-T therapy depending on the BT group. (A) Median PLT count over time depending on the BT group (non-CTX, intermediate CTX, and intensive CTX). Measured events per group and time point are provided in the table below. P values are shown to the right of the table and refer to comparisons of groups across time points and interactions between group and time points. Further statistical analyses using a linear mixed model are summarized in supplemental Table 8. Baseline, before LD. Day 0, day of CAR-T infusion. (B) Time to PLT recovery depending on the BT group. The dashed lines indicate the median values. HR, 95% CI, and P values for group comparisons are provided below the curves. The number of patients at risk per time point are listed in the table below. (C-D) Box plots showing the PLT count nadir values during the early (C) and late (D) post–CAR-T period depending on the BT group. The number of measurements per group and the P value of the group comparisons are given above. The framed numbers are the median values. The dashed lines indicate the threshold values for CTC grade 3 and grade 4 events. (E-G) The frequency of PLT transfusions during the late post–CAR-T period (E), TPO agonist administration (F), and autologous CD34+ stem cell boosts (G), depending on the BT group. The P value of the group comparison and, if indicated, the results of a contingency analysis, including ORs, 95% CI, and P value, are shown above. PLT, platelet; TPO, thrombopoietin receptor.

Recovery of PLTs after CAR-T therapy depending on the BT group. (A) Median PLT count over time depending on the BT group (non-CTX, intermediate CTX, and intensive CTX). Measured events per group and time point are provided in the table below. P values are shown to the right of the table and refer to comparisons of groups across time points and interactions between group and time points. Further statistical analyses using a linear mixed model are summarized in supplemental Table 8. Baseline, before LD. Day 0, day of CAR-T infusion. (B) Time to PLT recovery depending on the BT group. The dashed lines indicate the median values. HR, 95% CI, and P values for group comparisons are provided below the curves. The number of patients at risk per time point are listed in the table below. (C-D) Box plots showing the PLT count nadir values during the early (C) and late (D) post–CAR-T period depending on the BT group. The number of measurements per group and the P value of the group comparisons are given above. The framed numbers are the median values. The dashed lines indicate the threshold values for CTC grade 3 and grade 4 events. (E-G) The frequency of PLT transfusions during the late post–CAR-T period (E), TPO agonist administration (F), and autologous CD34+ stem cell boosts (G), depending on the BT group. The P value of the group comparison and, if indicated, the results of a contingency analysis, including ORs, 95% CI, and P value, are shown above. PLT, platelet; TPO, thrombopoietin receptor.

or Create an Account

Close Modal
Close Modal