Clec12a is required for NUP98::NSD1-induced leukemogenesis in vivo. (A) Survival of mice that received transplants of NUP98::NSD1+NRASG12D cells transduced with lacZ (n = 9) or Clec12a sgRNAs (n = 27; sgT6, n = 10; sgT44, n = 9; sgT47, n = 8). (B) WBC count in PB at the time of death in mice that received transplants of Clec12a WT and KO NUP98::NSD1+NRASG12D cells (mean ± SEM). (C) Hemoglobin levels in PB at the time of death in mice that received transplants of Clec12a WT and KO NUP98::NSD1+NRASG12D cells (mean ± SEM). (D) Platelet count in PB at the time of death in mice that received transplants of Clec12a WT and KO NUP98::NSD1+NRASG12D cells (mean ± SEM). (E) Average spleen weight at the time of death in mice that received transplants of Clec12a WT and KO NUP98::NSD1+NRASG12D cells (mean ± SEM). (F) Engraftment of dTomato⁺ cells in the BM, spleen, and PB of Clec12a WT and Clec12a KO NUP98NSD1+NRASG12D cells at the time of death. Some mice died before PB analysis could be performed.