Validation of early T-ICAHT in external cohorts. (A) Distribution of early T-ICAHT grades in patients with NHL treated with academic CAR-T at Sheba Medical Center. (B) Probability of OS by early T-ICAHT in patients with NHL treated with academic CAR-T at Sheba Medical Center. (C) Distribution of early T-ICAHT grades in patients with MM treated with BCMA CAR-Ts. (D) Probability of OS by early T-ICAHT in patients with MM treated with B-cell maturation antigen CAR-Ts. (E) Distribution of early T-ICAHT grades in adult and pediatric patients with ALL. (F) Probability of OS by early T-ICAHT in adult and pediatric patients with ALL. POC, point of care.