Distribution of IMWG hematologic responses based on frailty. Overall, 32 of the 40 frail patients (80%) and 45 of the 62 nonfrail patients (73%) showed at least a ≥50% reduction in circulating monoclonal protein levels based on IMWG response criteria. Among frail patients, 19 (48%) had VGPR, and 6 (15%) had either CR or sCR. Among nonfrail patients, 19 (31%) had VGPR, and 14 (23%) had either CR or sCR. There were no statistically significant differences in the distribution of response rates in each of the groups. PR, partial response; sCR, stringent CR; VGPR, very good partial response.