Figure 5.
Pharmacological inhibition of NAMPT leads to increased cytotoxicity in primary −7 patient cells. (A) Relative viability of primary human samples from patients with AML with and without −7 after treatment with 100 nM of KPT-9274 or DMSO control for 48 hours in liquid culture (n = 3-5 patients per group). (B) Relative viability of normal CD34+ hematopoietic samples treated with increasing concentrations of KPT-9274 for 48 hours in liquid culture (n = 3). (C) Total CFU numbers of primary human samples from patients with AML with and without −7 after treatment with 100 nM of KPT-9274 or DMSO vehicle control for 14 days in MethoCult H4434 (n = 3-4 patients per group). One-way ANOVA with Dunnett correction for multiple comparison tests was performed for statistical analysis among 4 independent groups.

Pharmacological inhibition of NAMPT leads to increased cytotoxicity in primary −7 patient cells. (A) Relative viability of primary human samples from patients with AML with and without −7 after treatment with 100 nM of KPT-9274 or DMSO control for 48 hours in liquid culture (n = 3-5 patients per group). (B) Relative viability of normal CD34+ hematopoietic samples treated with increasing concentrations of KPT-9274 for 48 hours in liquid culture (n = 3). (C) Total CFU numbers of primary human samples from patients with AML with and without −7 after treatment with 100 nM of KPT-9274 or DMSO vehicle control for 14 days in MethoCult H4434 (n = 3-4 patients per group). One-way ANOVA with Dunnett correction for multiple comparison tests was performed for statistical analysis among 4 independent groups.

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