Figure 3.
Copy number abnormalities in EMD and BMA samples, including significant CNAs and biallelic deletions specific to EMD. (A) Copy number abnormalities were more prevalent in EMD samples compared to BMAs. (B) Weighted CNB analysis revealed a significantly higher CNB in EMD samples than in BMA samples, reflecting the increased prevalence of genomic alterations. (C) Among EMD samples, significant gain/amplifications (red) were observed in the 1q region, whereas notable deletions/loss (blue) occurred in the 17p13 and 1p36 regions, among others. BMAs also demonstrated a significant peak in the 1q region, but the amplitude and frequency were notably lower than in EMD. (D) Select genes with biallelic alterations (mutation in 1 allele with loss of the other allele or biallelic loss) are shown. MAX was the most commonly affected putative tumor suppressor gene.

Copy number abnormalities in EMD and BMA samples, including significant CNAs and biallelic deletions specific to EMD. (A) Copy number abnormalities were more prevalent in EMD samples compared to BMAs. (B) Weighted CNB analysis revealed a significantly higher CNB in EMD samples than in BMA samples, reflecting the increased prevalence of genomic alterations. (C) Among EMD samples, significant gain/amplifications (red) were observed in the 1q region, whereas notable deletions/loss (blue) occurred in the 17p13 and 1p36 regions, among others. BMAs also demonstrated a significant peak in the 1q region, but the amplitude and frequency were notably lower than in EMD. (D) Select genes with biallelic alterations (mutation in 1 allele with loss of the other allele or biallelic loss) are shown. MAX was the most commonly affected putative tumor suppressor gene.

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