Incidence of maximum CRS grade by RO7283420 IV dose in group I patients. (A) At cycle 1 day 1. (B) At cycle 1 day 8 in patients who received previous 1 mg step-up dosing. (C) At cycle 1 day 15 in patients who received previous 1/3 mg DSU dosing. CRS, cytokine release syndrome; DSU, double step-up; IV, intravenous.