Kaplan-Meier survival curves illustrating survival outcomes of patients from the time of relapse. (A) OS (OS2) for all patients who received second-line treatment to the end of the follow-up. (B) OS2 is categorized by treatment intent, distinguishing between curative and palliative therapies. (C) OS2 stratified by age. (D) OS2 based on the time to first relapse.