RAS^mut were more prevalent in TP53^wt and are enriched in KMT2A-r. (A) RAS^mut were highly prevalent in TP53^wt compared with TP53^mut t-MNs; (B-C) most prevalent mutational hot spots (G12, G13, and Q61) in NRAS^mut and KRAS^mut (G12, G13, and Q61); (D) volcano plot comparing clinical, cytogenetic, and mutational profiles between TP53^mut and RAS^mut. Poor-risk cytogenetics were enriched in TP53^mut, whereas KMT2A-r and other somatic mutations are more frequent in RAS^mut t-MN; (E) complex karyotype (CK) was highly prevalent in TP53^mut but not in RAS^mut t-MN; (F) KMT2A-r was enriched in RAS^mut cases compared to TP53^mut and RAS^wt t-MN; and (G) t(9;11) was highly prevalent in KRAS^mut compared to NRAS^mut.