Figure 1.
Schematic representation of the investigated ABL2 fusion genes, the breakpoint regions, and their relevant domains. Domain organization of ABL2 fusion genes. The 5′ partner genes are highlighted. The KD (light green) and myristate pocket (black) were retained in all fusions. The PAG1::ABL2 and RCSD1::ABL2 fusions retained a partial SH2 domain (truncation at exon 5), whereas the ZC3HAV1::ABL2 fusion retained the complete SH3 and SH2 domains (truncation at exon 3). The generated ZC3HAV1::ABL2 Δ3 (ZΔ3; exon 3 deletion; truncation of SH3 domain) and Δ4 isoforms (ΖΔ4; exon 3 & 4 deletion; deletion of SH3 and truncation of SH2 domain) are also shown. The SH3 and SH2 domains are shown in red and yellow, respectively. The PAG1::ABL2 and RCSD1::ABL2 fusion genes are provided for comparison.

Schematic representation of the investigated ABL2 fusion genes, the breakpoint regions, and their relevant domains. Domain organization of ABL2 fusion genes. The 5′ partner genes are highlighted. The KD (light green) and myristate pocket (black) were retained in all fusions. The PAG1::ABL2 and RCSD1::ABL2 fusions retained a partial SH2 domain (truncation at exon 5), whereas the ZC3HAV1::ABL2 fusion retained the complete SH3 and SH2 domains (truncation at exon 3). The generated ZC3HAV1::ABL2 Δ3 (ZΔ3; exon 3 deletion; truncation of SH3 domain) and Δ4 isoforms (ΖΔ4; exon 3 & 4 deletion; deletion of SH3 and truncation of SH2 domain) are also shown. The SH3 and SH2 domains are shown in red and yellow, respectively. The PAG1::ABL2 and RCSD1::ABL2 fusion genes are provided for comparison.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal