Loss of CREBBP loading and EP300 compensation over regions of reduced H3K27Ac in CREBBP KAT-PM cells. (A-B) Heat maps (A) and density plots (B) of EP300 CUT&RUN in isogenic RL cells with CREBBP WT, KO, and different KAT-PMs (R1446C, Y1482N, Y1503C), showing regions from Figure 2A. (C-D) Heat maps (C) and density plots (D) of CREBBP CUT&RUN in isogenic RL cells with CREBBP WT, KO, and different KAT-PMs (R1446C, Y1482N, Y1503C), showing regions from Figure 2A. (E) Heat maps of the relative density of CREBBP loading in KAT-PM compared with WT CRISPR edited RL cells (left), primary FL tumors (middle), and DLBCL PDX models (right), showing all consensus CREBBP peaks in RL and HT cells. (F) Violin plots showing the RPKM of CREBBP CUT&RUN for WT and KAT-PM isogenic cell lines (left), primary FL biopsies (middle), and PDX models (right). P values were calculated with a Wilcoxon rank-sum test. Super-enh, super-enhancer.