Figure 5.
Exhaustion markers expressed in Vδ2+ cells and CD3+ cells before and after ZOL stimulation. (A) MFIs of the respective exhaustion markers reveal that ZOL-stimulated HH Vδ2+ T cells upregulate the exhaustion marker (HH n = 4) highly significantly compared with healthy controls (HD n = 3). (B) ZOL induces the significant and subset-specific expression of exhaustion markers in Vδ2+ cells but not in the CD3+ compartment of individuals with HH (n = 4) and, besides the activation marker Tim-3, neither in Vδ2+ cells nor in CD3+ cells of HDs (n = 3). The population designated as CD3+ includes all T cells except Vδ2+ cells, that is, αβ+, Vδ1+, and Vδ1–/Vδ2– T cells. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001; MFI, mean fluorescence intensity; ns, not significant.

Exhaustion markers expressed in Vδ2+ cells and CD3+ cells before and after ZOL stimulation. (A) MFIs of the respective exhaustion markers reveal that ZOL-stimulated HH Vδ2+ T cells upregulate the exhaustion marker (HH n = 4) highly significantly compared with healthy controls (HD n = 3). (B) ZOL induces the significant and subset-specific expression of exhaustion markers in Vδ2+ cells but not in the CD3+ compartment of individuals with HH (n = 4) and, besides the activation marker Tim-3, neither in Vδ2+ cells nor in CD3+ cells of HDs (n = 3). The population designated as CD3+ includes all T cells except Vδ2+ cells, that is, αβ+, Vδ1+, and Vδ1/Vδ2 T cells. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001; MFI, mean fluorescence intensity; ns, not significant.

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