Saliva reflected attenuated inflammation in the local oral environment and had reduced TGF-β1. (A) Correlation matrix of salivary cytokines in pretreatment and posttreatment cohorts. See correlation matrix key below “∗.” (B) Changes in selected salivary cytokines (IL-17A, TGF-β1, IL-1RL1/ST2, eotaxin-3, and MDC) with belumosudil treatment (n = 12; Wilcoxon signed-rank test was performed). (C) Correlation matrix among the changes in selected salivary cytokines, immune cells, and collagen in labial salivary glands between pretreatment and posttreatment cohorts. See correlation matrix key “∗.” (D) Scatterplots exploring relationships from panel C specific analytes in saliva and labial salivary glands with a significant positive correlation. ∗Correlation matrix key: the intensity of the colors and the diameter of the circles give an indication of the degree of correlation between 2 cytokines and reflect the strength of Spearman ρ correlation coefficient. The crosses represent correlation coefficients that were not statistically significant. Significance was tested using a Spearman rank test and level of significance was set at P value <.05. Paired nonparametric t test was performed. BAFF, B-cell activating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL-1RL1/ST2, interleukin 1 receptor-like 1/suppression of tumorigenicity 2; IP, IFN-γ–induced protein; MCP, monocyte chemoattractant protein; MDC, macrophage-derived chemokine; MIG, monokine induced by IFN-γ; MIP, macrophage inflammatory protein; TARC, thymus and activation-regulated chemokine; Tc17, type 17 cytotoxic effector cell; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.