Kinetic curves and parameters characterizing the shrinkage of thrombin-induced clots made from purified fibrinogen mixed with washed RBCs in the absence and presence of various concentrations of 100 kDa dextran. (А) Comparative kinetic curves and representative photographic images showing a shrunken clot from purified fibrin(ogen) mixed with 100 kDa dextran and RBCs (left) vs an unshrunken clot from purified fibrin(ogen) mixed with RBCs only. (B) Kinetic curves of RBC-induced clot shrinkage (extent of clot shrinkage over time) at various dextran concentrations. (C) The extent of clot shrinkage after 1 hour. (D) Lag time of clot shrinkage after addition of thrombin. (E) Average shrinkage rate. The results from 5 duplicated independent experiments are presented as the mean ± standard error of the mean and analyzed with the ordinary 1-way analysis of variance test with Tukey multiple comparisons post hoc test.