Nonhematological toxicity. (A) Bar plot of relative frequencies of nonhematological toxicity grade 3 to 4; enteritis/colitis (using Common Terminology Criteria for Adverse Events [CTCAE] V 3.0 criteria; P = .09 [2-sided Fisher exact test, α level, .05]); and relative frequencies of nonhematological grade 3 to 4 toxicity; other categories (using CTCAE V 5.0 criteria) of patients being treated with (red column) or without (blue column) an induction regimen including GO in the single-center analysis. (B) Bar plot of relative frequencies of grade 4 enteritis/colitis (using CTCAE V 5.0; P = .12 [2-sided Fisher exact test, α level, .05]); and relative frequencies of neutropenic enterocolitis⁴ (P = .13 [2-sided Fisher exact test, α level, .05]) of patients treated with GO (red column) or without GO (blue column) as part of the induction therapy in the single-center analysis. (C) Bar plot of relative frequencies of GI toxicity grade ≥3 (including diarrhea, nausea/vomiting, enteritis/colitis, and stomach pain using CTCAE V5; P = .03 [χ² test]) and relative frequencies of GI toxicity grade 4 (P = .1 [Fisher exact test]) of patients treated with GO (red column) or without GO (blue column) as part of the induction therapy in the multicenter analysis. ALT, alanine aminotransferase; AST, aspartate aminotransferase; GI Tox., gastro intestinal toxicity; NEC, neutropenic enterocolitis.