Figure 1.
Differential expression of miRNA in HbAS. (A) Heat map of differentially expressed plasma miRNAs in sickle cell anemia compared with the normal HbAA. (B) Bubble plot of significant KEGG pathway enrichment analysis (top 25). Characteristics of the HbAS cohort (n = 12) were as follows: mean age, 41 ± 7 years; 42% female; and mean eGFR, 101 ± 19 mL/min. The normal HbAA cohort (n = 12) had a mean age of 42 ± 8 years, 42% female, and a mean eGFR of 116 ± 17 mL/min. All 24 participants self-identified as Black race, were not on any chronic medications, and had no history of comorbidities. FC, fold change; miRNA, microRNA; U/D, up/down.

Differential expression of miRNA in HbAS. (A) Heat map of differentially expressed plasma miRNAs in sickle cell anemia compared with the normal HbAA. (B) Bubble plot of significant KEGG pathway enrichment analysis (top 25). Characteristics of the HbAS cohort (n = 12) were as follows: mean age, 41 ± 7 years; 42% female; and mean eGFR, 101 ± 19 mL/min. The normal HbAA cohort (n = 12) had a mean age of 42 ± 8 years, 42% female, and a mean eGFR of 116 ± 17 mL/min. All 24 participants self-identified as Black race, were not on any chronic medications, and had no history of comorbidities. FC, fold change; miRNA, microRNA; U/D, up/down.

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