Transaminases and platelet count trends before and after eculizumab administration. Time 0 indicated the time of eculizumab administration. Delivery is noted with an arrow. Corticosteroid administration is represented by the yellow circle. In patient 3, corticosteroids were administered 6 days before eculizumab. The values of platelets (×10⁹/L), AST (units per liter), and ALT (units per liter) are shown. ALT, alanine aminotransferase; AST, aspartate aminotransferase.