Figure 3.
A 2-way cooperative effect of 5B9 and 1E12 enhances their binding to platelets. Platelet binding of (A) labeled-DG-5B9 (n = 5) and (C) labeled-DG-1E12 (n = 8) alone or in the presence of 1E12, 5B9, or their F(ab’)2 fragments or IV.3. Inhibitory effect of ibrutinib on the platelet binding (B) of labeled-DG-5B9 with or without 1E12 or UFH + PF4 (n = 7) (D) of labeled-DG-1E12 with or without 5B9 (n = 7). Data are the median (minimum to maximum) of the MFI ratio. Mann-Whitney U test was used to compare the different conditions tested. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001.

A 2-way cooperative effect of 5B9 and 1E12 enhances their binding to platelets. Platelet binding of (A) labeled-DG-5B9 (n = 5) and (C) labeled-DG-1E12 (n = 8) alone or in the presence of 1E12, 5B9, or their F(ab’)2 fragments or IV.3. Inhibitory effect of ibrutinib on the platelet binding (B) of labeled-DG-5B9 with or without 1E12 or UFH + PF4 (n = 7) (D) of labeled-DG-1E12 with or without 5B9 (n = 7). Data are the median (minimum to maximum) of the MFI ratio. Mann-Whitney U test was used to compare the different conditions tested. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001.

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