Figure 2.
Cross-linking of 5B9 and 1E12 with FcγRIIA is essential for their synergistic Ab effect. (A) Platelet activation measured by SRA (n = 10) and (B) flow cytometry assay (CD62P expression, n = 13). 5B9 and 1E12 were tested alone or together, without or with IV.3 (10 μg/mL) or their F(ab’)2 fragments. (C) Platelet activation (CD62P expression, n = 4) induced by 5B9 and 1E12 alone or together, without or with ibrutinib. 5B9 with UFH and PF4 was tested as a positive control. Mann-Whitney U test was performed to compare the different conditions tested. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001.

Cross-linking of 5B9 and 1E12 with FcγRIIA is essential for their synergistic Ab effect. (A) Platelet activation measured by SRA (n = 10) and (B) flow cytometry assay (CD62P expression, n = 13). 5B9 and 1E12 were tested alone or together, without or with IV.3 (10 μg/mL) or their F(ab’)2 fragments. (C) Platelet activation (CD62P expression, n = 4) induced by 5B9 and 1E12 alone or together, without or with ibrutinib. 5B9 with UFH and PF4 was tested as a positive control. Mann-Whitney U test was performed to compare the different conditions tested. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001.

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