Figure 2.
Characterization of aged Gata2+/− transplanted mice. (A) Representative example of the transplantation assay performed with aged WT and Gata2+/− mice. (B) PB chimerism analysis performed over the months in WT and Gata2+/− mice. (C) Total WBC count analyzed over the time in WT and Gata2+/− mice. (D) Analysis of the different donor blood cell subsets performed in PB 7 months after primary transplantation in WT and Gata2+/− mice. (E) Analysis of the different blood cells subsets from PB smears 7 months after primary transplantation in WT and Gata2+/− mice. (F) BM chimerism analyzed 7 months after transplantation. (G) Analysis of the donor aged HSC BM compartment 7 months after primary transplantation in WT and Gata2+/− mice. (H) Representative example of the secondary transplantation assay performed with aged WT and Gata2+/− mice. (I) PB chimerism analysis performed in WT and Gata2+/− mice. (J) Total WBC count analyzed over the time in WT and Gata2+/− mice. (K) Donor B-cell analysis from PB 4 months after secondary transplantation in WT and Gata2+/− mice. (L) Analysis of the different donor blood cell subsets performed in PB 4 months after secondary transplantation in WT and Gata2+/− mice. (M) Schematic representation of B-cell differentiation in WT and Gata2+/− mice. (N) Donor B-cell differentiation in BM after secondary transplantation in WT and Gata2+/− mice. (O) Donor B-cell senescence analyzed 4 months after secondary transplantation in WT and Gata2+/− mice. (P) BM chimerism analyzed after secondary transplantation in WT and Gata2+/− mice. (Q) Analysis of aged donor HSC BM compartment 4 months after secondary transplantation. (R) Analysis of the different donor blood cell subsets performed in PB 4 months after secondary transplantation in WT and Gata2+/− mice. IgM, immunoglobulin M; WBC, white blood cell.

Characterization of aged Gata2+/− transplanted mice. (A) Representative example of the transplantation assay performed with aged WT and Gata2+/− mice. (B) PB chimerism analysis performed over the months in WT and Gata2+/− mice. (C) Total WBC count analyzed over the time in WT and Gata2+/− mice. (D) Analysis of the different donor blood cell subsets performed in PB 7 months after primary transplantation in WT and Gata2+/− mice. (E) Analysis of the different blood cells subsets from PB smears 7 months after primary transplantation in WT and Gata2+/− mice. (F) BM chimerism analyzed 7 months after transplantation. (G) Analysis of the donor aged HSC BM compartment 7 months after primary transplantation in WT and Gata2+/− mice. (H) Representative example of the secondary transplantation assay performed with aged WT and Gata2+/− mice. (I) PB chimerism analysis performed in WT and Gata2+/− mice. (J) Total WBC count analyzed over the time in WT and Gata2+/− mice. (K) Donor B-cell analysis from PB 4 months after secondary transplantation in WT and Gata2+/− mice. (L) Analysis of the different donor blood cell subsets performed in PB 4 months after secondary transplantation in WT and Gata2+/− mice. (M) Schematic representation of B-cell differentiation in WT and Gata2+/− mice. (N) Donor B-cell differentiation in BM after secondary transplantation in WT and Gata2+/− mice. (O) Donor B-cell senescence analyzed 4 months after secondary transplantation in WT and Gata2+/− mice. (P) BM chimerism analyzed after secondary transplantation in WT and Gata2+/− mice. (Q) Analysis of aged donor HSC BM compartment 4 months after secondary transplantation. (R) Analysis of the different donor blood cell subsets performed in PB 4 months after secondary transplantation in WT and Gata2+/− mice. IgM, immunoglobulin M; WBC, white blood cell.

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