OS and multivariate analysis. Kaplan-Meier OS curves for (A) ELN 2017, (B) ELN 2022, (C) ELN 2024, and (D) refined ELN 2024 risk criteria. The global P value is shown. A vertical tick mark indicates censoring. (E) Forest plot summarizing the results from a multivariate Cox proportional hazards model adjusted for genes mutated at a frequency >5%. The hazard ratio (HR) is represented as a blue square, while the 95% CI is displayed as a horizontal line. An HR of <1 indicates that mutated genes confer a longer OS than the reference group (wildtype). Conversely, an HR of >1 suggests a shorter OS than the reference group.