Enrichment of the PD, ID, and balance scores during CLL trafficking. (A-C) PD, ID, and B score comparisons between paired samples extracted from PB and the LN (A); between paired samples of the sorted proliferative and resting CLL fractions (B); and between CLL proliferative and resting fractions identified at the single-cell level (C). P values were obtained using paired 2-tailed Student t tests; (D) HRs and P values for univariate Cox regression models using the different scores as predictors of TTFT in the proliferative and resting CLL fractions. The scores were standardized as a z score for easier comparison and interpretation. P values were calculated using the Wald test. Prolif., proliferative.