Genomic features associated with DLBCL-IQs. (A) Alluvial plot showing overlap between LymphGen subtypes and DLBCL-IQs. (B) Forest plot showing genetic alterations recurrently associated with ABC hot or ABC cold DLBCLs. (C) Forest plot showing genetic alterations recurrently associated with GCB hot or GCB cold DLBCLs. (D) Bar plot of GSEA showing gene sets significantly enriched in each immune-related cluster. (E) GSEA plots showing upregulation of G2M target gene sets in ABC cold and GCB cold DLBCLs. (F) GSEA plots showing upregulation of MYC checkpoint-related genes in ABC cold and GCB cold DLBCLs. The Fisher exact test with BH-adjusted P values is displayed. ∗adjusted P < .1; ∗∗adjusted P < .05. BD, Benjamini-Hochberg; ES, enrichment score; NES, normalized enrichment score; OR, odds ratio.