Transcriptomic analysis identifies 4 unique DLBCL immune environments. (A) PCA biplot showing the contribution of immune-related gene sets and COO-related gene sets to PC1 and PC2, respectively. (B) Confusion matrix showing the concordance between GSVA-based COO classification and molecularly defined COO designations for all DLBCLs in the discovery cohort (NCI/UCMC, N = 577). (C) PCA plot showing concordance between sample-wise GSVA COO scores and molecularly defined COO calls for all DLBCLs in the discovery cohort. Clusters are defined by the dashed line. (D) PCA plot showing sample-wise GSVA enrichment scores for DLBCLs in the discovery cohort, labeled by IQ name (ABC cold, dark blue; ABC hot, red; GCB cold, light blue; GCB hot, yellow). (E) Heat map showing sample-wise GSVA enrichment scores for all 19 gene sets.