T-cell activation markers during treatment. (A) CD4⁺ and (B) CD8⁺ in patients treated with Pola-M-CHP vs Pola-R-CHP. Paired t tests were performed on paired samples collected predose and 2 hours postdose during cycles 1 and 2. Boxes represent the 25th percentile, median, and 75th percentile, with the shaded regions showing the interquartile range. Plus signs represent mean values. Whiskers extend to the minimum and maximum values. ∗P = .01-.05; ∗∗∗∗P < .0001.