Bacterial community characteristics and association with 1-year mortality and acute GHVD. (A) Bacterial classes significantly associated with survival 1 year after HSCT from forearm skin sites. Statistical significance based on adjusted P values for unrestricted permutation are displayed. (B) Hierarchical clustering of plasmid-borne ARGs from forearm skin site at pre-HSCT time point. (C) Estimation of subspecies/strain-level growth rate for C acnes strains and association with aGVHD from forearm skin site. A higher SMEG score indicates a higher growth rate. Each data point represents a subspecies cluster. Significant differences at pretransplant, 1-week, 1-month, and 3-month time points were computed with Wilcoxon rank sum test. Overall P value (P = .204) between groups, accounting for multiple measures was computed based on unrestricted permutation. (D) Distribution of a C acnes cluster over time as a function of aGVHD from forearm skin sites. MLS, macrolides, lincosamides, streptogramines; mo, months; SMEG, strain-level metagenomic estimation of growth rate; wk, weeks.