Mutation patterns and effect on all Tier 1 genes. Genes in Tier 1 on any of the FL, DLBCL, or BL lists are shown. Because genes can exist in >1 list and may not be assigned the same tier, the tier for each entity is indicated on the right (Tier 1, green; Tier 2, yellow; Tier 3, amber). The heat map shows the proportion of cases with mutations in that gene is shown above each entity with deeper red indicating a higher incidence. Genes known to be affected by aberrant somatic hypermutation (aSHM) are indicated with a gray rectangle to the right. The existence of functional data is indicated on the far right. The color shows whether mutations have been functionally determined to represent a loss of function (violet), gain of function (red), or neomorph (yellow). The studies demonstrating this result for these genes are as follows: ARID1A,^68,ID3,^51,TCF3,^51,CCND3,^51,FOXO1,^69,GNA13,^59,S1PR2,^59,RHOA,^59,P2RY8,^59,KMT2D,^70,71,SMARCA4,^72,BCL6,^73,BCL7A,^74,DDX3X,^66,FBXO11,^75,TFAP4,^76,CREBBP,^77,78,EP300,^28,EZH2,^79,80,IRF8,^81,PIM1,^82,BTG1,^83,84,CDKN2A,^85,CD79B,^86,DTX1,^87,NOTCH1,^43,POU2AF1,^88,POU2F2,^89,B2M, CD58,^47,BCL10,^90,CARD11,^25,FAS,^91,RRAGC,^60,ATP6V1B2,^60,ATP6AP1,^60,STAT6,^92,TBL1XR1,^93,TNFAIP3,^94,KLHL6,^95,MEF2B,^96,SGK1,^97,SOCS1,^98,MYD88,⁹⁹ and TMEM30A.¹⁰⁰ The citations for these and all remaining genes are included in the supplemental Tables.