Orphan genes and the usual suspects. (A) The shared and orphan genes obtained by intersecting gene lists from the first 6 large DLBCL studies (top) and the remaining 6 studies (bottom). Each set of studies is also intersected with the current Tier 1 DLBCL gene list. The genes in each intersection are also identified by red or blue circles on panel C. (B) The number of DLBCL genes in Tier 1 and the full list is shown at the time of each of the 12 large studies.^{2,3,5-7,16,18-23} The totals at each time point include genes that were identified previously or in other contemporaneous studies that are not part of this figure. The citations for studies that nominated these additional genes are as follows: FAS,^24,CARD11,^25,CXCR4,^26,PIM1,^27,CREBBP/EP300,^28,EZH2,^29,MYD88,^30,BCL2,^31,IL4R,^32,NFKBIZ,^33,MS4A1,^34,XPO1,^35,BRAF,^36,PRDM1,^37,TNFAIP3,^38,MYC,²⁷ and STAT6.³⁹ (C) For each column below a study in panel B, the Tier 1 DLBCL genes newly introduced by the study are grouped together and indicated in the corresponding color. For all subsequent studies, a gene is colored violet if it was on the significantly mutated gene (SMG) list of that study, which is considered a confirmation of that gene. The total number of confirming studies is indicated next to each gene using a gradient.