Summary of fatigue. (A) FACIT-Fatigue responder analysis in C5i-experienced patients from the 168-day randomized treatment period in APPLY-PNH. (B) Cumulative distribution of changes from baseline in FACIT-Fatigue scores by treatment and visit in APPLY-PNH. (C) FACIT-Fatigue responder analysis in C5i-naive patients from the 168-day randomized treatment period in APPOINT-PNH. bid, twice daily. C5i, C5 inhibitor; eCDF, empirical Cumulative Distribution Function; FACIT-Fatigue, Functional Assessment of Chronic Illness-Fatigue; RBC, red blood cell. ^a Proportions are mean of days 126, 140, 154, and 168, including RBC transfusion. ^b An eCDF represents the proportion of observations that fall below each unique value in a dataset. The red line represents the 9-point MWPC threshold for the FACIT-Fatigue. Higher FACIT-Fatigue scores represent less fatigue. P values are from the Mann-Whitney test that compares proportions with FACIT-Fatigue improvements of ≥ 9 points.