Figure 3.
The prognostic and survival significance of C3 in patients with HLH. (A) Overall survival (OS) analysis of HLH associated with various triggers. (B) OS analysis indicated that the low C3 group had a high risk of death. (C) The mortality rates between the low C3 group and the high C3 group at 8 weeks, 1 year, and overall death. (D) The forest plot of the univariate and multivariate Cox regression analysis. (E) The dynamic changes in C3 levels were analyzed from pre-onset to HLH onset (N = 66) and from HLH onset to post-treatment in patients (N = 47) who survived for 8 weeks (n = 36) and those who died within 8 weeks (n = 11). Day 0 represented the day of diagnosis, negative values represented days before diagnosis, and positive values represented days after diagnosis. ∗∗P < .01; ∗∗∗P < .001. 95% CI, 95% confidence interval; BUN, blood urea nitrogen; Cr, creatinine; Tbil, total bilirubin.

The prognostic and survival significance of C3 in patients with HLH. (A) Overall survival (OS) analysis of HLH associated with various triggers. (B) OS analysis indicated that the low C3 group had a high risk of death. (C) The mortality rates between the low C3 group and the high C3 group at 8 weeks, 1 year, and overall death. (D) The forest plot of the univariate and multivariate Cox regression analysis. (E) The dynamic changes in C3 levels were analyzed from pre-onset to HLH onset (N = 66) and from HLH onset to post-treatment in patients (N = 47) who survived for 8 weeks (n = 36) and those who died within 8 weeks (n = 11). Day 0 represented the day of diagnosis, negative values represented days before diagnosis, and positive values represented days after diagnosis. ∗∗P < .01; ∗∗∗P < .001. 95% CI, 95% confidence interval; BUN, blood urea nitrogen; Cr, creatinine; Tbil, total bilirubin.

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