Kaplan-Meier curves for the major secondary end point comparing the 12- and 3-month edoxaban groups in the subgroups stratified by D-dimer levels at 3 months. (A) Low D-dimer subgroup. (B) High D-dimer subgroup. The major secondary end point is major bleeding as defined according to the International Society on Thrombosis and Haemostasis criteria, and consists of fatal bleeding, symptomatic bleeding in a critical area or organ, and bleeding causing a reduction in hemoglobin levels by ≥2 g/dL or leading to a transfusion of ≥2 units of whole blood or red cells.