Kaplan-Meier curves for persistent edoxaban discontinuation comparing the 12- and 3-month edoxaban groups in the subgroups stratified by D-dimer levels at 3 months. (A) Low D-dimer subgroup. (B) High D-dimer subgroup. Time-to-event curves for persistent edoxaban discontinuation. Persistent edoxaban discontinuation is defined as the discontinuation of edoxaban according to the study protocol or lasting >14 days for any reason.