Figure 4.
Structural impact of the p.R564L mutation on JAK2 protein.JAK2 p.R564I leads to disruption of local structure. (A) Ribbon diagram of full-length JAK2 (amino acids, 1-1132; UniProt ID O60674) modeled using AlphaFold,27,28 followed by loop refinement using Modeller.29,30 Coloring corresponds with the regional pLDDT score as shown in the key. (B) The amino acids within 5 Å of arginine 564 are highlighted and shown with ball and stick models. Hydrogen-bond and van der Waals interactions are depicted as dashed lines. The p.R564L mutation is expected to disrupt key interactions with nearby residues including His538, E566, Y613, T576, and His574, altering the local structural integrity.

Structural impact of the p.R564L mutation on JAK2 protein.JAK2 p.R564I leads to disruption of local structure. (A) Ribbon diagram of full-length JAK2 (amino acids, 1-1132; UniProt ID O60674) modeled using AlphaFold,27,28 followed by loop refinement using Modeller.29,30 Coloring corresponds with the regional pLDDT score as shown in the key. (B) The amino acids within 5 Å of arginine 564 are highlighted and shown with ball and stick models. Hydrogen-bond and van der Waals interactions are depicted as dashed lines. The p.R564L mutation is expected to disrupt key interactions with nearby residues including His538, E566, Y613, T576, and His574, altering the local structural integrity.

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