Cellular interactions between malignant cells and TME cells. (A) UMAP plot of T-cells colored by T-cell subtypes. (B) Bar chart shows abundance of clonotypes by the expansion status in each T-cell subcluster. (C) Quantification of TCR similarity index (Morisita index) between each pair of T-cell subclusters. (D) UMAP plot of macrophage/microglia colored by the cell subtypes. (E) Violin plot shows the marker gene expression of each subcluster. (F) Left bubble plot shows the significant interaction among tumor B-cells. Middle bubble plot shows the enhanced interaction of the malignant B-cells with the TME. Right bubble plot shows the significant interaction of the immune cells with the tumor B-cells. (G) Chord diagram and violin plot of interactions associated with TNFSF13B (BAFF) and TNFSF13 (APRIL). (H) Chord diagram and violin plot of CD70-CD27 interactions. (I) Chord diagram and violin plot of SPP1-CD44 interactions. CD4+T_naive, CD4⁺ naïve T-cell; CD8+T_pre_exh, CD8⁺ pre-exhausted T-cell; CD8+T_eff, CD8⁺ effector T-cell; CD8+T_exh, CD8⁺ exhausted T-cell; DC, dendric cell; Mono, monocyte; prolif_T, proliferative T-cell; Treg, regulatory T-cell.