Preceding RTI caused by SARS-CoV-2 worsened stroke outcomes, alleviated by VWF deficiency and aggravated by ADAMTS13 deficiency. (A) Schematic of experimental design. (B-D) Left: representative 2,3,5-Triphenyltetrazolium chloride (TTC)-stained coronal brain sections after 45 minutes of ischemia followed by 23 hours of reperfusion (n = 7-10 mice per group). The white area indicates an infarct. Middle: infract volume quantification. Right: neurological Bederson score of the same mouse groups on day 1 after reperfusion (n = 7-10 mice per group). Data are presented as mean ± SEM (middle) or median and range (right). Statistical analysis was performed with an unpaired t test for panels B-C (middle) or Mann-Whitney U test (right).