Body iron status in different diabetic mouse models. Male mice treated by (A-D) STZ, (E-H) male db/db mice, and (I-L) KKAy mice were studied in comparison with their corresponding controls (Cont). (A,E,I) Blood glucose, (B,F,J) serum iron, and (C,G,K) liver nonheme iron levels were determined. Perls iron staining was performed to show the magnitude of iron deposition in the liver of diabetic and control mice for panels D,H,L. Data are expressed as mean ± standard error of the mean (SEM; n = 4-7 mice per group). ∗P < .01 compared with the corresponding controls. Red arrows denote Kupffer cells in the liver of db/db mice. Bars, 100 μm.